High efficiency catalytic synthesis of the 6-isopropyl-3,4-dihydropyrimidones

CHEN Xiaoxia; HUANG Qingjun; WU Zhuo

doi:10.3969/j.issn.2096-3424.2023.014

CHEN Xiaoxia, HUANG Qingjun, WU Zhuo. High efficiency catalytic synthesis of the 6-isopropyl-3,4-dihydropyrimidones[J]. Journal of Technology, 2024, 24(2): 190-196. DOI: 10.3969/j.issn.2096-3424.2023.014

Citation:

High efficiency catalytic synthesis of the 6-isopropyl-3,4-dihydropyrimidones

Graphical Abstract

Graphical Abstract

Abstract

Abstract

A novel and simple catalytic methodology to highly efficient synthesis of the 6-isopropyl-3,4-dihydropyrimidines via Biginelli condensation using efficient, eco-friendly 4,5-methano-L-prolines as catalyst under solvent-free condition has been developed. A variety of compounds with excellent biological activity was obtained in good to excellent high yields (up to 99 %) under mild conditions.