Efficient synthesis of 1,4-dihydropyridines catalyzed by microwave and ionic liquids

KANG Liqin; NI Yuwei; DING Huamin

doi:10.3969/j.issn.2096-3424.2022.072

KANG Liqin, NI Yuwei, DING Huamin. Efficient synthesis of 1,4-dihydropyridines catalyzed by microwave and ionic liquids[J]. Journal of Technology, 2024, 24(2): 185-189. DOI: 10.3969/j.issn.2096-3424.2022.072

Citation:

Efficient synthesis of 1,4-dihydropyridines catalyzed by microwave and ionic liquids

Graphical Abstract

Graphical Abstract

Abstract

Abstract

2,6-dimethyl-4-3ˊ-nitrophenyl-N³,N⁵-diphenyl-3,5-diformamide dihydropyridine was synthesized from 3-nitrobenzaldehyde, 3-oxygen-N-phenylbutanamide and ammonium acetate via Hantzsch reaction in the presence of ionic liquid with pyridine as the mother under microwave irradiation. The corresponding structure of the product is characterized by ¹H-NMR. Compared by the methods in the literature, this method has a simple reaction process, short reaction time, high yield, and easy reuse.