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    手性香料的不對稱催化合成研究進展

    Progress on the Asymmetric Catalytic Synthesis of Chiral Flavors and Fragrances

    • 摘要: 手性香料已在化妝品🦵🏻、食品和醫藥等中得到了廣泛的應用。由於人的嗅覺和味覺受體是由手性分子構成💯,不同對映異構體香料其香氣存在差異🏋🏼‍♀️。因此👩‍👩‍👦‍👦🙆🏿‍♂️,為了避免手性香料“無效”異構體帶來的潛在風險👰‍♀️,以及降低香料的使用量,減少廢物排放和保護環境,發展手性香料高效異構體的不對稱合成方法顯得尤為重要🔛。隨著不對稱催化合成技術發展,其在手性香料高效異構體的合成上也得到了越來越多的應用。本文以L-薄荷醇、二氫茉莉酮酸甲酯、麝香酮、玫瑰醚等手性香料為例介紹手性香料的不對稱催化合成研究進展。

       

      Abstract: Chiral flavors and fragrances have been widely used in cosmetics, food, medicine, etc. Because human olfactory and taste receptors are made up of chiral biomolecules, the aromas of different enantiomers of chiral flavors and fragrances are not the same. Therefore, in order to avoid the potential risks caused by the "ineffective" enantiomers of chiral flavors and fragrances, reduce the use and discharge of wastes, and protect the environment, it is particularly important to develop efficient methods for the asymmetric synthesis of chiral flavors and fragrances. Great progress has been achieved in the field of catalytic asymmetric catalysis in last decades. A number of catalytic asymmetric reactions have been applied to the synthesis and productions of enantiomeric pure chiral flavors and fragrances. In this paper, we briefly review the progress on the study of catalytic asymmetric synthesis of chiral flavors and fragrances including L-methanol, methyl dihydrojasmonate, muscone, rose oxide, etc.

       

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